解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::C4d deposition in peritubular capillaries (PTC) has been used as a marker of antibody-mediated rejection (AMR). However, PTC C4d deposition is not described in patients with lupus nephritis (LN). C4d deposition in PTC was detected in 455 patients with biopsy proven LN in the present study. Renal tissues from 21 cases ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307083279
更新日期:2007-01-01 00:00:00
abstract::Panniculitis rarely occurs in the course of systemic lupus erythematosus (SLE). When it occurs, it is thought to be mainly lupus erythematosus panniculitis (LEP). Here we describe a 32-year old Japanese woman with chronic SLE, who simultaneously presented facial lymphocytic lobular panniculitis and pancytopenia due to...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307077560
更新日期:2007-01-01 00:00:00
abstract::Neuropsychiatric lupus is a well-recognized complication of systemic lupus erythematosus (SLE) and encompasses a wide variety of neurological manifestations. Although isolated cranial nerve involvement is rare, it can cause significant morbidity and disability. This report describes a case with isolated vagus nerve in...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307080632
更新日期:2007-01-01 00:00:00
abstract::A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307081421
更新日期:2007-01-01 00:00:00
abstract::Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203307079039
更新日期:2007-01-01 00:00:00
abstract::Pancreatitis is a relatively rare complication in systemic lupus erythematosus (SLE). Here we present a case of SLE associated with autoimmune pancreatitis. A 37-year old woman was admitted to our hospital because of fever, skin rash, proteinuria and abdominal pain. A diagnosis of SLE was made based on her clinical, l...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306073137
更新日期:2007-01-01 00:00:00
abstract::Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe infections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Dam...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/09612033070160040201
更新日期:2007-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiff...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306071402
更新日期:2006-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2299oa
更新日期:2006-01-01 00:00:00
abstract::The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Among the thrombogenic mechanisms proposed, it has been suggested that aPL can stimulate tissue factor (TF) expression by endothelial cells (ECs) and monocytes. Moreover, ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203306lu2276rr
更新日期:2006-01-01 00:00:00
abstract::The aim of this study was to describe the clinical course of patients with lupus nephritis (LN) who attain a sustained remission (SR) and identify predictors of SR. A retrospective study of patients with biopsy-proven LN were followed for up to 10 years. SR was defined as normal renal function, urine protein <0.5g/day...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2271oa
更新日期:2006-01-01 00:00:00
abstract::We performed a prospective study to evaluate the efficacy and safety of low-dose cyclosporine A (CSA) treatment in paediatric lupus nephritis refractory to conventional therapy. Seven children with biopsy-proven Class III-IV lupus nephritis were treated with CSA (2-4 mg/kg/day) combined with low-dose prednisone for on...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2312oa
更新日期:2006-01-01 00:00:00
abstract::There has been limited success defining environmental factors important to the development of connective tissue diseases such as systemic lupus erythematosus (SLE). Recent work has suggested that the perinatal environment may be important. To investigate this we measured antinuclear antibodies (ANA) in a general popul...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2286oa
更新日期:2006-01-01 00:00:00
abstract::Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and para...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203306lu2331oa
更新日期:2006-01-01 00:00:00
abstract::Congenital heart block occurs in fetuses of Ro/SSA and La/SSB positive women. To investigate the stability of maternal autoantibody levels during pregnancy, we followed Ro52, Ro60 and La autoantibody IgG level variation and Ro52 subclass profiles longitudinally in selected congenital heart block risk pregnancies. Seru...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2309oa
更新日期:2006-01-01 00:00:00
abstract::The Framingham risk score is widely used to identify patients at increased cardiovascular risk, and women with systemic lupus erythematosus (SLE) have a marked increased prevalence of cardiovascular events. Thus, we examined the hypothesis that cardiovascular risk scores would identify women with SLE who had asymptoma...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306071870
更新日期:2006-01-01 00:00:00
abstract::The object of this study was to compare patients with familial versus sporadic systemic lupus erythematosus (SLE) with respect to clinical, laboratory variables and outcome. The familial SLE group comprised 12 patients while the comparative group comprised 24 patients selected by systemic sampling from our pediatric r...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330607192
更新日期:2006-01-01 00:00:00
abstract::Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306071314
更新日期:2006-01-01 00:00:00
abstract::The objective of this study was to examine factors predictive of a decline to low levels of disease activity in a cohort of systemic lupus erythematosus (SLE) patients. Patients with SLE of Hispanic (from Texas or Puerto Rico), African-American or Caucasian ethnicity from a multiethnic cohort were included. A decline ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2256oa
更新日期:2006-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is one of the most heterogeneous autoimmune disorders known. There is production of a variety of autoantibodies and patients present with a wide range of symptoms due to multiple organ involvement by the disease process. The underlying cause is not fully understood but it may involve...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203306072311
更新日期:2006-01-01 00:00:00
abstract::Concerns regarding the safety and efficacy of immunization in patients with SLE have persisted for over 60 years, despite the increased risk of infection in these patients. There are many anecdotal case reports of SLE induction or exacerbation following immunization, but overall, these events seem to be very rare. Evi...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203306069355
更新日期:2006-01-01 00:00:00
abstract::Estrogens and their receptors may play a role in the pathogenesis of systemic lupus erythematosus. Genetic alterations in the exon 8-coding region of the estrogen receptor alpha alter the intracellular signalling of estrogens, leading in enhanced or diminished activity. We investigated whether genetic alterations in e...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2104oa
更新日期:2005-01-01 00:00:00
abstract::Severe systemic lupus erythematosus often requires the use of cyclophosphamide in women of reproductive age. As cyclophosphamide is generally avoided during pregnancy because of its teratogenic risk, its impact on fetal survival is poorly understood. This is a case series of lupus patients exposed to cyclophosphamide ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2169oa
更新日期:2005-01-01 00:00:00
abstract::The objective of this study was to assess the prevalence, clinical, histological and immunological characteristics, and the long-term outcome of polymyositis- (PM) and dermatomyositis- (DM) associated lung disease, and to define subgroups of lung-associated inflammatory myopathies. This retrospective study included 81...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2158oa
更新日期:2005-01-01 00:00:00
abstract::The aim of the study is to investigate whether the functional p53 codon 72 polymorphism is associated with susceptibility to SLE and its clinical features. A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the p53 codon 72 in 90 SLE patients and 114 ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2224oa
更新日期:2005-01-01 00:00:00
abstract::The metabolism of radioiodinated mouse IgG was studied in mice with lupus-like syndrome before and after the onset of the disease. Before the onset of the disease, the pharmacokinetic parameters of IgG in MLR-1pr and Pristane-primed Balb/c mice were within the normal range of values. After the onset of the disease a c...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2129oa
更新日期:2005-01-01 00:00:00
abstract::Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expresse...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2193oa
更新日期:2005-01-01 00:00:00
abstract::The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2203oa
更新日期:2005-01-01 00:00:00
abstract::Atherosclerosis is recognized as the pathological basis of cardiovascular disease (CVD) and recent advances in basic science have shown that it should be considered as a chronic inflammatory process. Both elements of the innate and the adaptive immunity appear to be actively involved in atherogenesis. In fact, the pot...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2213oa
更新日期:2005-01-01 00:00:00
abstract::Thiazolidinediones (TZDs) are selective ligands of peroxisome-proliferator-activated receptor gamma increasingly used in the treatment of type 2 diabetes. Both in vitro and in vivo studies provide evidence that TZDs have anti-inflammatory properties. TZDs inhibit macrophage activation and decrease inflammatory cytokin...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2223oa
更新日期:2005-01-01 00:00:00
abstract::There is an increasing body of literature suggesting the efficacy and tolerability of mycophenolate mofetil (MMF) for the treatment of lupus nephritis. The rationale for its use is based upon its successful profile as an immunosuppressive agent for prevention of allograft rejection, as well as studies in murine models...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2061oa
更新日期:2005-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoreactive T cell mediated autoimmune disease. Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reaction to deplete specific subsets of autoreactive T cells involved in SLE. Six SLE patients unsuitable or refused to use immunosuppressants ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203305lu2239oa
更新日期:2005-01-01 00:00:00
abstract::We report the case of a fetus with proliferative glomerulonephritis in the context of maternal systemic lupus erythematosus (SLE). The pattern of the renal lesions correspond to the class III of revisited WHO classification of glomerulonephritis in SLE. Amniotic fluid analysis showed a high level of albumin and the pr...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu2045cr
更新日期:2005-01-01 00:00:00
abstract::Mycophenolate mofetil (MMF) initially found widespread use in the immunoprophylaxis of rejection in organ transplantation. It has subsequently been used in lupus glomerulonephritis, where early studies have shown it to be effective in induction and maintenance therapy. The randomized studies have mostly studied small ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2116oa
更新日期:2005-01-01 00:00:00
abstract::Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2073oa
更新日期:2005-01-01 00:00:00
abstract::The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1006oa
更新日期:2004-01-01 00:00:00
abstract::The objective of the study was to analyse the prevalence and clinical significance of hypocomplementemia in a large series of patients diagnosed either with systemic lupus erythematosus (SLE) or with primary antiphospholipid syndrome (APS) and its association with the main clinical, hematological and immunological fea...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1080oa
更新日期:2004-01-01 00:00:00
abstract::The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu2037sa
更新日期:2004-01-01 00:00:00
abstract::We report the occurrence of visceral leishmaniasis in three patients coming from the northern part of Italy treated with immunosuppressive drugs for different rheumatic conditions. This paper highlights the importance of adequate work-up in those patients presenting with serious clinical manifestations that can compli...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu518oa
更新日期:2004-01-01 00:00:00
abstract::CD27 is a useful marker in assessing the number of circulating B cells and B cell subsets because it permits one step identification of the major B cell compartments, CD27- naïve and CD27+ memory B cells as well as CD27high plasma cells. Abnormalities in the distribution ofCD27+ B cell subsets are useful in assessing ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu1014oa
更新日期:2004-01-01 00:00:00